Hydroxypropyl methyl cellulose (HPMC)|RONAS CHEMICALS IND.CO.,LTD.

Hydroxypropyl methyl cellulose (HPMC)
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Description of Hydroxypropyl methyl cellulose (HPMC)

Formula of Hydroxypropyl methyl cellulose (HPMC) : C6H7O2(OH)x(OCH3)y(OC3H7)z x+y+z=3
F.W. of Hydroxypropyl methyl cellulose (HPMC) : 162.14
CAS no. of Hydroxypropyl methyl cellulose (HPMC) : 9004-65-3
DOT of Hydroxypropyl methyl cellulose (HPMC) : Nill
NFPA no. of Hydroxypropyl methyl cellulose (HPMC) : 1-0-0
Class no.of Hydroxypropyl methyl cellulose (HPMC) : Nill
UN no. of Hydroxypropyl methyl cellulose (HPMC) : Nill
HS code of Hydroxypropyl methyl cellulose (HPMC) : 39123900
Specific Gravity of Hydroxypropyl methyl cellulose (HPMC) : 1.26-1.31

Physical Properties:
1.Appearance:HPMC is a white or light gray pellet or fibril power with odorless and tasteless.
2.Solubility:hardly dissolves in waterless ethanol,ether or acetone.Expands as to clear or slightly muddy colloid solution in cold water.It can dissolve in some organic solvents or some water-organic components.
3.Pellet:100 screen passable rate is over 98.5%,80 screen passable rate is 100%.
4.Density:0.30-0.70g/cm3,Density:1.26-1.31g/cm3.

Properties
1.Water keeping ability:HPMC is a high water keeping agent whose drug level products are widely used in applications of food,cosmetic products and many other aspects.
2.Membranous ability:HPMC can be formed to transparent,tough,flexible film that can be reliably prevent grease from enter.During food storage,the properties are used to keep water and absorb oil.
3.Felting ability:HPMC is also a good felting ingredient,which is used to formed drug and food.

Dissolving process
HPMC will agglomerate when directly added to water and then dissolve.In this way it dissolves very slow and hard,Suggested methods as followers:
1.In hot water .Add water in container to 1/3 or 2/3 of its content.Heated to over 80oC.Because HPMC doesn't dissolve in hot water,It uniformly disperses in hot water,Add cool water or ice to the residual content,stir and cool down the mixture.
2.Powder combination.Mix HPMC with identical volume of other powder,disperses them sufficiently then add water to the mixture result HPMC dissolves without agglomeration.
3.organic solvent wet.Dispersed or wet with organic solvents such as ethanol,glycol or oil,then add water can cause HPMC completely dissolves.

Specification of Hydroxypropyl methyl cellulose (HPMC)

usp24, EP, JP , Industry grade
Items	Types
Items	E/2910/60	F/2906/65	K/2208/75
Methoxyl content(WT%)	28.0-30.0	27.0-30.0	19.0-24.0
Hydroxypropoxyl content(WT%)	7.0-12.0	4.0-7.5	4.0-12.0
Gelation temperature(oC)	58.0-64.0	62.0-68.0	70.0-90.0
PH value(1% solution ,25oC)	4.0-8.0
Ash content(WT%)	0.5 (1.0-Industry grade) max
Loss on drying (WT%)	5.0 max
Burnt residues(WT%)-pharm grade	1.5 max
Heavy metal(PPM)-pharm grade	20 max
Arsenic(PPM)-pharm grade	2 max
Viscosity :(2% solution at 20oC)
Item		Specification	Range
Low Viscosity CPS		5	4-6
		10	8-12
		15	12-18
Middle Viscosity CPS		25	20-30
		50	40-60
		100	80-120
High Viscosity CPS		4000	3200-4800
High Viscosity CPS		12000	9600-14400
Extra-high Viscosity CPS		20000	16000-24000
		25000	22000-28000
		30000	27000-32000
		40000	38000-42000
		50000	47000-52000
		60000	57000-62000
		75000	72000-78000

Application of Hydroxypropyl methyl cellulose (HPMC)

Hydroxypropyl methyl cellulose (HPMC) are widely used in food ,cosmetic and other daily use chemical lines,Typical usage as following:
1.Medical drug.
The product is a medical accessory material of may uses.It can be used for densifiers,dispersing reagent,emulsifying reagent,Lubricator and former etc,It's used as an adhesive and coating film in tablets,increasing markedly rate of dissolution and release,and strengthen water proof for tablets and also be used as mixed dispersing reagent ,eye drop reagent,controlled released matrix tablets,It is combined with other synthetic polymers and gel-type drug products to prevent ethanol separated from transparent gel drug while improve water keep ability.
2.Foodstuff & Whip-topping.
HPMC can be directly used to food & Whip-topping as effective emulsification reagent ,adhesive,thickening reagent as well as can be used as packing materials.
3.Cosmetic.
According to properties of HPMC,it can be used as thickening agent,emulsification reagent,suspending reagent,stabilizing reagent,water retention reagent,rheological behavior reagent,Thus be used in all kinds of cosmetic products(cream and ointment).
4.Industry grade
Construction industry

Packing&Storage of Hydroxypropyl methyl cellulose (HPMC)

Packing of Hydroxypropyl methyl cellulose (HPMC) :
20kg or 25kg package in polyethylene bag or barrel with inner liners

Storage of Hydroxypropyl methyl cellulose (HPMC) :
Keep dry where good ventilated ,Do not wet ,and keep from sunshine when transport.

MSDS of Hydroxypropyl methyl cellulose (HPMC)

Material Safety Data Sheets of Hydroxypropyl methyl cellulose (HPMC)

Section 1 - Chemical Product
MSDS Name: Hydroxypropyl Methyl Cellulose

Section 2 - Company Identification
Molecular Formula£ÜC6H7O2(OH)x(OCH3)y(OC3H7)z x+y+z=3
Synonyms: None.
CAS# Chemical Name Percent EINECS/ELINCS
9004-65-3 Hydroxypropyl Methyl Cellulose - unlisted

Section 3 - Hazards Identification
Hazard Symbols: None listed.
Risk Phrases: None listed.

EMERGENCY OVERVIEW
Appearance: white to off-white powder. Caution! The toxicological properties of this material have not been fully investigated. May cause eye and skin irritation. May cause respiratory and digestive tract irritation.
Target Organs: No data found.
Potential Health Effects
Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin: May cause skin irritation. The toxicological properties of this material have not been fully
investigated.
Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic: No information found.

Section 4 - First Aid Measures
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 1; Flammability: 0; Instability: 0
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment
section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 6 - Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 7 - Exposure Controls, Personal Protection
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Hydroxypropyl Methyl Cellulose none listed none listed none listed
OSHA Vacated PELs: Hydroxypropyl Methyl Cellulose: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 8 - Physical and Chemical Properties
Physical State: Powder
Appearance: white to off-white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: chloroform
Specific Gravity/Density:Not available.
Molecular Formula:Not available.
Molecular Weight:Not available.

Section 9 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 10 - Toxicological Information
RTECS#: CAS# 9004-65-3: NF9125000
LD50/LC50: Not available.
Carcinogenicity: CAS# 9004-65-3: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: No information available.
Neurotoxicity: No information available.
Mutagenicity: No information available.
Other Studies: No data available.

Section 11 - Ecological Information
No information available.

Section 12 - Disposal Considerations
discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 13 - Transport Information
US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: No information available. No information available.
Hazard Class:
UN Number:
Packing Group:

Section 14 - Regulatory Information
US FEDERAL
TSCA
CAS# 9004-65-3 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.

Section 15
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.

Section 16
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 9004-65-3 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
S 28A After contact with skin, wash immediately with
plenty of water.

Hydroxypropyl methyl cellulose (HPMC) raw mateiral

1)Methylcellulose and propylene oxide

Hydroxypropyl methyl cellulose (HPMC) end goods

Omeprazole

Substitute of Hydroxypropyl methyl cellulose (HPMC)

Other cellulose goods,such as HEC,EC,CMC,MC,etc.

Importing & exporting rules of Hydroxypropyl methyl cellulose (HPMC)

Normal
Note: Provided that buyers have other requirements, negotiation might be necessary between Supplier and Buyer.

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