|
|
||||
|
SYNONYMS: |
Natriumpyruvat; Piruvato de
sodio; Pyruvate de sodium;2-Oxopropanoic acid, sodium salt; |
|
|
|
|
CAS NO.: |
113-24-6 |
|
||
|
EINECS NO.: |
204-024-4 |
|
||
|
FORMULA: |
CH3COCOONa |
|
||
|
H.S. CODE: |
2918.30 |
|
||
|
CLASS NO.: |
N/A |
|
||
|
UN NO.: |
N/A |
|
||
|
NFPA: |
2-1-0-E |
|
||
|
DESCRIPTION: |
white to off-white crystalline powder. Pyruvic acid is a liquid with acetic-acid smell; melting point 11 - 12 C; solube in water. It occurs naturally as an intermediate product in carbohydrate and protein metabolism in the body. The six-carbon glucose molecule is broken down to two molecules of pyruvic acid in aerobic condition as the main input for Krebs cycle, whereas to two molecules of lactic acid (alpha hydroxy acid) in anaerobic condition. Krebs cycle (also called citric acid cycle; tricarboxylic acid cycle) is a sequent process of enzymatic reaction which a two-carbon acetyl unit is oxidized to carbon dioxide and water to provide energy in the form of high-energy phosphate bonds. |
|||
|
|
||||
|
APPLICATION |
||||
|
In commercial, pyruvic acid is used to produce its salts and esters (pyruvates) for the use as dietary supplements of the effective weight loss enhancers . Pyruvic acid is used for the synthesis of amino acids (alanine, tyrosine, phenylalanine, and tryptophan) and used in biochemical research. Its derivatives are used in making food additives and flavoring agents. |
||||
|
SPECIFICATION & PACKING |
||||
|
APPEARANCE: white to off-white crystalline powder ASSAY: 99.0% min LOSS ON DRYING: 1.0% max HEAVY METALS: 10ppm max CHLORIDE: 30ppm max SULFATE ASH: 0.01% max WATER: 0.5% max Packing: 25g,50g. Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agent |
||||
|
RAW MATERIAL: |
N/A |
|||
|
END GOODS: |
N/A |
|||
|
REMARKS: |
N/A |
|||
|
MATERIAL SAFE DATA SHEETS |
||||
Section 1: Chemical Product and Company Identification
Product Name: Sodium pyruvate
CAS#: 113-24-6
Synonym: Natriumpyruvat;
Piruvato de sodio; Pyruvate de sodium;
2-Oxopropanoic acid, sodium salt; Pyruvic Acid Sodium Salt;
Chemical Formula: C3H3NaO3
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Sodium pyruvate 113-24-6 100
Toxicological
Data on Ingredients: Sodium pyruvate LD50: Not available. LC50: Not
available.
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of eye contact (irritant).
Potential Chronic Health Effects:
Very hazardous in case of ingestion.
Hazardous in case of skin contact (irritant), of inhalation.
Slightly hazardous in case of eye contact (irritant).
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL
TOXICITY: Not available.
Section 4: First Aid Measures
Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used.
Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.Wash contaminated clothing before reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation: Not available.
Ingestion:
Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious
Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2). Some metallic oxides.
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special
Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with skin Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible.
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away
from strong oxidizing agents.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure
Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Crystalline solid.)
Odor: Not available.
Taste: Not available.
Molecular Weight: 110.05 g/mole
Color: White.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Decomposes.
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility:
Easily soluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization:
No.
Section 11: Toxicological Information
Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals:
LD50: Not available.
LC50: Not available.
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans:
Very hazardous in case of ingestion.
Hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special
Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special
Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste
Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special
Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory: Sodium pyruvate
Other Regulations: Not available..
Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
DSCL (EEC): R38- Irritating to skin.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Safety
glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
|
SPECIAL DESCRIPTION |
Pyruvic acid is a low mole weight alpha keto acid (ketone along with carboxylic acid). It contains a ketone bond on the carbon atom next to the acid group. If the ketone is on the second carbon next to the acid group, it is called beta-keto acid.
Members of alpha-keto acid
|
alpha-keto acid |
CAS RN |
|
Pyruvic acid |
127-17-3 |
|
Phenylpyruvic acid |
156-06-9 |
|
4-Hydroxyphenylpyruvic acid |
156-39-8 |
|
Glyoxylic acid |
298-12-4 |
|
alpha-Ketoglutaric acid |
328-50-7 |
|
Oxalacetic acid |
328-42-7 |
|
Indol-3-ylpyruvic acid |
392-12-1 |
|
2-Keto-L-gulonic acid |
526-98-7 |
|
Phthalonic acid |
528-46-1 |
|
2-Keto-4-methylthiobutyric acid |
583-92-6 |
|
alpha-Ketobutyric acid |
600-18-0 |
|
Phenylglyoxylic acid |
611-73-4 |
|
Phenylglyoxylic acid |
611-73-4 |
|
alpha-Ketoisovalerate |
759-05-7 |
|
Hydroxydiiodophenylpyruvic acid |
780-00-7 |
|
alpha-Ketoisocaproic acid |
816-66-0 |
|
3-Deoxy-2-octulosonic acid |
1069-03-0 |
|
Vanilpyruvic acid |
1081-71-6 |
|
2-Hydroxy-4-oxopentanedioic acid |
1187-99-1 |
|
alpha-Keto-beta-methylvaleric acid |
1460-34-0 |
|
alpha-Oxofuran-2-acetic acid |
1467-70-5 |
|
2-Ketopentanoic acid |
1821-02-9 |
|
beta-Hydroxy-alpha-ketobutyric acid |
1944-42-9 |
|
Vanilglycolic acid |
2021-40-1 |
|
alpha-Ketocaproic acid |
2492-75-3 |
|
3-Deoxy-D-arabino-2-heptulosonic acid 7-phosphate |
2627-73-8 |
|
alpha-Ketoadipic acid |
3184-35-8 |
|
alpha-Keto-delta-guanidinovaleric acid |
3715-10-4 |
|
alpha-Oxothiophen-2-acetic acid |
4075-59-6 |
|
3,4-Dihydroxyphenylpyruvic acid |
4228-66-4 |
|
2-Keto-4-mercaptobutyric acid |
4273-28-3 |
|
alpha-Oxocyclohexaneacetic acid |
4354-49-8 |
|
2-Nitrophenylpyruvic acid |
5461-32-5 |
|
Ketohypoglycin |
5746-24-7 |
|
3,4-Didehydro-2-ketoglutaric acid |
6004-32-6 |
|
4-chloro-alpha-oxobenzeneacetic acid |
7099-88-9 |
|
4-Methylbenzoylformic acid |
7163-50-0 |
|
3-Deoxy-2-ketoarabinonic acid |
7636-04-6 |
|
Amidinophenylpyruvic acid |
10290-63-8 |
|
4-Hydroxyphenylglyoxylic acid |
15573-67-8 |
|
Provitamin C |
16533-48-5 |
|
4-Aminophenylpyruvic acid |
16921-36-1 |
|
3-Deoxy-D-erythro-2-hexulosonic acid |
17510-99-5 |
|
4-(((Aminoiminomethyl)amino)oxy)-2-oxobutanoic acid |
17774-31- |
|
5-Amino-2,5-dioxopentanoic acid |
18465-19-5 |
|
2-Ketogluconate |
20248-27-5 |
|
2-Keto-4-pentenoic acid |
20406-62-6 |
|
3-Deoxyglycero-galactononulosonic acid |
22594-61-2 |
|
Ketomycin |
23364-22-9 |
|
N-Acetylisatic acid |
32375-61-4 |
|
N-4-Chlorobenzoylisatinic acid |
54778-24-4 |
|
N-Benzoylisatinic acid |
54778-23-3 |
|
2-Keto-3-butynoic acid |
56842-75-2 |
|
2-Keto-3-deoxyoctonic acid 5-phosphate |
57717-01-8 |
|
2-Oxo-4-hydroxyarginine |
64186-82-9 |
|
2-Keto-3-bromobutanoic acid |
71183-36-3 |
|
alpha-Ketokainic acid |
75232-58-5 |
|
3-Bromo-2-ketopentanedioic acid |
76444-16-1 |
|
alpha-Ketosuberic acid |
96406-05-2 |
|
2-Keto-3-deoxy-1,7-dicarboxyheptonic acid |
99778-26-4 |
|
4-(chloromethyl)-alpha-oxobenzeneacetic acid |
114996-73-5 |
|
5-Hydroxy-6-(2-keto-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid |
117675-20-4 |
|
Clavicoronic acid |
139748-98-4 |