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SYNONYMS: |
Noroxin;
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7- |
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CAS NO.: |
70458-96-7 |
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EINECS NO.: |
274-614-4 |
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FORMULA: |
C16H18FN3O3 |
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H.S. CODE: |
30049090 |
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CLASS NO.: |
N/A |
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UN NO.: |
N/A |
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NFPA: |
1-1-0 |
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DESCRIPTION: |
off-white to yellow crystals. |
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APPLICATION |
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Norfloxacin, the second generation drug of the quinolone antibiotics, is the virus reverse transcriptase inhibitor. |
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SPECIFICATION & PACKING |
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APPEARANCE: white to off-white crystals IDENTIFICATION: Complies Test A,B ASSAY: 98.0% min LOSS ON DRYING: 1.0% max RELATED SUBSTANCE: 0.5% max HEAVY METALS: 15ppm max SULFATED
ASH: 0.5% max Storage: Store in original container in a cool dark place. |
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RAW MATERIAL: |
N/A |
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END GOODS: |
N/A |
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REMARKS: |
N/A |
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MATERIAL SAFE DATA SHEETS |
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CHEMICAL INDENTIFICATION
Product Name NORFLOXACIN
Synonyms : Noroxin; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Norfloxacino; Norfloxacine;
COMPOSITION/INFORMATION ON INGREDIENTS
C.A.S. No 70458-96-7
Molecular Formula : C16H18FN3O3
Formula Weight: 319.33
HAZARDS IDENTIFICATION
Not considered hazardous when handled under normal conditions with good house keeping.
Label precautionary statements:
FIRST-AID MEASURES
In case of inhalation:
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
In case of contact with skin:
Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
In case of contact with eyes:
Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
In case of ingestion:
If swallowed, wash out mouth with water, provided person is concious. Seek medical advice.
Remove and
wash/dispose of contaminated clothing promptly.
FIRE FIGHTING MEASURES
Extinguishing Media:
Carbon dioxide, dry chemical powder or appropriate foam. Water spray.
Unusual fire and explosion hazards:
Emits toxic fumes under fire conditions
Special fire fighting procedures:
Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.
ACCIDENTAL RELEASE MEASURES
Ensuring personal safety, mark out contaminated area with signs and prevent unauthorised access. Turn leaking containers up to prevent further Evaculate area. Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves. Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pick-up complete.
HANDLING AND STORAGE
Store in original container in a cool dark place.
EXPOSURE CONTROL/PERSONAL PROTECTION
Respiratory protection:
required when dusts are generated.
Eye protection:
required.
Hand protection:
required.
Industrial hygiene:
Immediately change contaminated clothing. Wash hands and face after working with substance.
PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Odour
Melting Point
Solubility
STABILITY AND REACTIVITY
Conditions to be avoided:
Unknown
Substances to be avoided:
Unknown
Hazardous decomposition products:
Unknown
TOXICOLOGICAL INFORMATION
N/A
ECOLOGICAL INFORMATION
Do not allow product to enter drinking water supplies, waste water or soil!
DISPOSAL CONSIDERATIONS
Dissolve or mix material with a suitable combustible solvent and incinerate in a chemical incinerator equipped with an afterburner and scrubber.
Material should be disposed of in keeping with all local and national legislation. Packaging should be disposed of in keeping with all local and national legislation. Handle contaminated containers as product.
TRANSPORT INFORMATION
Classification: N/A
UN Number: N/A
REGULATORY INFORMATION
N/A
OTHER INFORMATION
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.S
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SPECIAL DESCRIPTION |
Fluoroquinolones
belong to a group of synthetic antibiotics that are derived from basic
structure of nalidixic acid and have substituents at N-1, C-5, C-7, position 8
and a fluorine atom at position 6. There are also polycyclic derivatives.
Quinolone antibiotics have a ketone at position 4 and a carboxylic group at
position 3. Fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase
IV enzyme, resulting the inhibition of DNA replication and transcription.
Fluorine at position 6 enhances gyrase inhibition and cell penetration.
Piperaziny substituents provide activity against Gram-negative bacteria
and pyrrolidinyl moiety is active against Gram-positive cocci. They improve
water solubility needed oral application. The function substituted at position
8 IS to control anaerobe activity.
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Fluoroquinolone |
Substituent |
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Substituted at N-1 |
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Norfloxacin |
Ethyl |
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Enoxacin |
Ethyl |
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Lomefloxacin |
Ethyl |
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Fleroxacin |
Fluoro ethyl |
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Difloxacin |
Fluorophenyl |
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Temafloxacin |
Difluorophenyl |
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Trovafloxacin |
Difluorophenyl |
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Amifloxacin |
Methyl amino |
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Ciprofloxacin |
Cyclopropyl |
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Grepafloxacin |
Cyclopropyl |
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Alumofloxacin |
Cyclopropyl |
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Gemifloxacin |
Cyclopropyl |
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Moxifloxacin |
Cyclopropyl |
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Ecenofloxacin |
Cyclopropyl |
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Balofloxacin |
Cyclopropyl |
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Substituted at C-5 |
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Sparfloxacin |
Amine |
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Grepafloxacin |
Methyl |
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Substituted at C-7 |
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Trovafloxacin |
Bicyclic |
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Moxifloxacin |
Bicyclic |
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Danafloxacin |
Bicyclic |
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Garenoxacin |
Bicyclic |
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Ciprofloxacin |
Piperazinyl |
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Lomefloxacin |
Piperazinyl |
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Norfloxacin |
Piperazinyl |
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Fleroxacin |
Piperazinyl |
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Ofloxacin |
Piperazinyl |
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Sparfloxacin |
Piperazinyl |
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Grepafloxacin |
Piperazinyl |
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Gatafloxacin |
Piperazinyl |
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Levofloxacin |
Piperazinyl |
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Clinafloxacin |
Pyrrolidinyl |
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Nadifloxacin |
Pyrrolidinyl |
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Sitafloxacin |
Pyrrolidinyl |
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Irloxacin |
Pyrryl |
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Balofloxacin |
Piperidinyl |
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Substituted at position 8 |
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Sparfloxacin |
F |
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Lomefloxacin |
F |
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Fleroxacin |
F |
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Ciprofloxacin |
CH2 |
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Temafloxacin |
CH2 |
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Pefloxacin |
CH2 |
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Norfloxacin |
CH2 |
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Grepafloxacin |
CH2 |
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Clinafloxacin |
Cl |
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Sitafloxacin |
Cl |
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Enoxacin |
N |
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Tosufloxacin |
N |
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Gemifloxacin |
N |
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Trovafloxacin |
N |
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Ecenofloxacin |
N |
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Alatrofloxacin |
N |
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Gatifloxacin |
Methoxy |
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Pazufloxacin |
Methoxy |
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Balofloxacin |
Methoxy |
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Moxifloxacin |
Methoxy |
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Garenoxacin |
Methoxy |
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Tricyclic derivatives |
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Abufloxacin |
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Droxacin |
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Flumequine |
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Levofloxacin |
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Marbofloxacin |
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Miloxacin |
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Ofloxacin |
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Oxolinic acid |
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Pazufloxacin |
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Prulifloxacin |
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Rufloxacin |
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Verbafloxacin |
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Norfloxacin, the second generation drug of the quinolone antibiotics, is the virus reverse transcriptase inhibitor
CLINICAL APPLICATIONS;
-Uncomplicated urinary tract infections
-Complicated urinary tract infections
-Pyelonephritis
-sexually transmitted diseases
-prostatitis
-skin and tissue infections
-Urethral and cervical gonococcal infections