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SYNONYMS: |
Neobiotic;
Otobiotic. Mycifradin sulfate; O-2,6-diamino-2,6-dideoxy-.beta.-L- |
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CAS NO.: |
1405-10-3 |
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EINECS NO.: |
215-773-1 |
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FORMULA: |
C23H52N6O25S3 |
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H.S. CODE: |
29419000 |
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CLASS NO.: |
N/A |
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UN NO.: |
N/A |
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NFPA: |
2-1-0-E |
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DESCRIPTION: |
Neomycin sulfate is a white to
yellowish powder; hygroscopic; very soluble in water; slightly soluble in
alcohol; insoluble in acetone. |
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APPLICATION |
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Neomycin is applied topically to
the skin, conjunctiva, and ears in the treatment of infections due to
susceptible organisms. It is used in combination with other antibiotics or
antiinflammatory steroids. Neomycin sulfate is administered orally in
preoperative bowel preparation. |
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SPECIFICATION & PACKING |
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APPEARANCE: white to yellowish powder ASSAY: 680 μm/mg min (Anhydrous potency) IDENTIFICATION: positive (Test A, Test B,) SULFATE: 27.0 - 31.0% STREPTOMYCIN B: 3.0% max pH: 5.0 - 7.0 RELATED SUBSTANCES: Neomycin C: 3.0 - 15.0% Neamine : 2.0% max Total Impurity: 15.0% max LOSS ON DRYING: 8.0% max OPTICAL ROTATION: +53.5º ~ +59.0º SULFATED ASH: 1.0% max RESIDUE ON IGNITION:
1.0% max Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. |
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RAW MATERIAL: |
N/A |
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END GOODS: |
N/A |
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REMARKS: |
N/A |
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MATERIAL SAFE DATA SHEETS |
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Section 1: Chemical Product and Company Identification
Product Name: Neomycin sulfate
CAS#: 1405-10-3
Synonym:
Chemical Name: Not available.
Chemical Formula: C23H52N6O25S3
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Neomycin sulfate 1405-10-3 100
Toxicological
Data on Ingredients: Neomycin sulfate LD50: Not available. LC50:
Not available.
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of ingestion. Hazardous in case of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact (irritant, permeator).
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Section 4: First Aid Measures
Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.
Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated
clothing before reusing.
Serious Skin Contact: Not available.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation: Not available.
Ingestion:
Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious
Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2,SO3...).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special
Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible.
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away
from strong oxidizing agents.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure
Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 908.87 g/mole
Color: Not available.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Decomposes.
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not
available.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization:
No.
Section 11: Toxicological Information
Routes of Entry: Eye contact. Inhalation. Ingestion.
Toxicity to Animals:
LD50: Not available.
LC50: Not available.
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans:
Very hazardous in case of ingestion.
Hazardous in case of inhalation.
Slightly hazardous in case of skin contact (irritant, permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Excreted in maternal milk in animal.
Special
Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste
Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special
Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Neomycin sulfate
California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Neomycin sulfate
TSCA 8(b) inventory: Neomycin sulfate
Other Regulations: Not available..
Other Classifications:
WHMIS (Canada): CLASS D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC): R36- Irritating to eyes.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
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SPECIAL DESCRIPTION |
Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit. They include;
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Aminoglycoside antibiotic |
CAS RN. |
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Adechlorin |
96328-17-5 |
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Gentamicin |
1403-66-3 |
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Netilmicin |
56391-56-1 |
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Gentamicin sulfate |
1405-41-0 |
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Amikacin |
37517-28-5 |
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Apramycin |
37321-09-8 |
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Butirosin sulfate anhydrous |
51022-98-1 |
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Chlorothricin |
34707-92-1 |
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Dibekacin |
34493-98-6 |
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Dihydrostreptomycin Sulfate |
5490-27-7 |
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Framycetin |
119-04-0 |
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Geneticin |
49863-47-0 |
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Hygromycin A |
6379-56-2 |
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Hygromycin B |
31282-04-9 |
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Isepamicin |
58152-03-7 |
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Kanamycin |
59-01-8 |
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Nebramycin |
11048-13-8 |
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Neomycin |
1404-04-2 |
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O-Demethylchlorothricin |
134637-04-0 |
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O-Demethylhydroxychlorothricin |
134615-17-1 |
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Paromomycin |
7542-37-2 |
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Puromycin |
53-79-2 |
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Ribostamycin |
25546-65-0 |
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Sisomicin |
32385-11-8 |
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Streptomycin |
57-92-1 |
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Streptozocin |
18883-66-4 |
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Tobramycin sulfate |
49842-07-1 |
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Tobramycin |
32986-56-4 |
Neomycin analogues or derivatives;
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Product |
CAS RN. |
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Neomycin C |
66-86-4 |
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Framycetin |
119-04-0 |
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Fradicin |
1403-61-8 |
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Neomycin |
1404-04-2 |
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Bacitracin |
1405-87-4 |
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Neomycin sulfate |
1405-10-3 |
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Neomycin, hydrochloride |
1406-02-6 |
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Neomycin undecylenate |
1406-04-8 |
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Streptonigrin |
3930-19-6 |
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Neamine |
3947-65-7 |
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Paromomycin |
7542-37-2 |
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Predni aquos opthiole |
8024-67-7 |
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Cortisporin |
8024-64-4 |
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Synalar N |
8025-20-5 |
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Nebacetin |
8025-63-6 |
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Cicatrin |
8055-43-4 |
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Mixture (neomycin, polymyxin, bacitracin) |
8057-37-2 |
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Neoterramycin |
8057-00-9 |
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Proctosedyl |
8058-05-7 |
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Vibrocil |
8059-14-1 |
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Pimafucort |
8072-88-6 |
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Hexasalicylideneneomycin |
11041-92-2 |
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Neomycin B hydrochloride |
25389-99-5 |
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Ribostamycin |
25546-65-0 |
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Neomycin B sulfate |
28002-70-2 |
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3'-O-Methylneamine |
37085-86-2 |
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4'-O-Methylneamine |
37085-87-3 |
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1-N-(s)-4-Amino-2-hydroxybutyryl-3'4'-deoxyneamine |
42859-94-9 |
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Butirosamine |
50474-68-5 |
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Mixture (neomycin, polymyxin) |
51273-62-2 |
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Statrol |
51484-67-4 |
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Neomycin F |
51795-47-2 |
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Polyspectrin |
52218-57-2 |
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Diaropect |
52503-65-8 |
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Betnovate-N |
53262-69-4 |
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Neomycin B-glucoside |
53861-54-4 |
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L-N(sup 1)-(4-Amino-2-hydroxybutyryl)-4'-deoxyneomycin A |
54333-80-1 |
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4'-Deoxy-5-O-xylosylneamine |
54333-81-2 |
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Neomycin palmitate |
55298-68-5 |
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Ribosylparomamine |
55781-25-4 |
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Dodeca-N-methylneomycin hexamethochloride |
57270-93-6 |
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Dimethylaminopropylneomycin |
57285-81-1 |
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Tresaderm |
57571-74-1 |
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Kanamycin phosphotransferase II |
58943-39-8 |
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Neomycin C hydrochloride |
63121-20-0 |
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Neomycin 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid |
71750-54-4 |
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Cysto-myacyne |
76391-80-5 |
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Dontisolon |
76403-99-1 |
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Framycort |
77536-65-3 |
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Neomycin-pantothenate |
78149-94-7 |
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Vineomycin A1 |
78164-00-8 |
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neomedrol-veriderm |
78232-14-1 |
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Neo-medrol |
78232-16-3 |
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Oterna |
78371-70-7 |
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Pulpomixine |
78515-94-3 |
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6'''-Deamino-6'''-hydroxyparomomycin I |
78524-72-8 |
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6'''-Deamino-6'''-hydroxyneomycin B |
78524-73-9 |
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Maxitrol |
78666-15-6 |
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Mixture(neomycin, nystatin, polymyxin, acetarsol, dimethicone) |
78891-94-8 |
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Sofradex |
79173-16-3 |
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3',4'-dideoxyparomomycin |
80451-74-7 |
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Vineomycin B2 |
80928-52-5 |
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Vineomycin B1 |
81457-63-8 |
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Vineomycin A2 |
81457-62-7 |
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Trofodermin |
84057-92-1 |
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Dansylparomomycin |
85166-09-2 |
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Neotil |
85883-86-9 |
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Panotile |
99401-18-0 |
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3-N-methylparomomycin I |
106288-50-0 |
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Polyspectran OS |
117733-87-6 |
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Mixture(colistin sulfate, neomycin sulfate, hydrocortisone acetate, thonzonium bromide) |
119509-48-7 |
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(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione neomycin sulfate / polymyxin sulfate |
123354-95-0 |
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Fokalmin |
126663-41-0 |
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Dexapolyspectran |
143305-95-7 |