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 IVERMECTIN

SYNONYMS:

22,23-Dihydroxy-avermectin B;
5 -O-demethyl-22,23-dihydro- avermectin A;

 

 

CAS NO.:

70288-86-7  , 70161-11-4 (B1a), 70209-81-3 (B1b)

 

EINECS NO.:

274-536-0 , 274-384-5

 

FORMULA:

A mixture of Ivermectin components

B(1a) ,C48H74O14, and B(1b), C47H72O14.

 

H.S. CODE:

29419090

 

CLASS NO.:

6.1

 

UN NO.:

UN2811, PG II

 

NFPA:

3-1-0

 

DESCRIPTION:

Toxic solid, white crystalline powder.
Avermectin: any of a group of pentacyclic sixteen-membered lactones derived from the soil bacterium Streptomyces avermitilis. Abamectin is the mixture of individual avermectin B1a(more than 90%) and avermectin B1b (not more than 10%) components. A-series compounds are methoxylated at 5 position, whereas the B-series have an underivatized hydroxyl group at the position. The 1-subset compound has an olefinic bond between C22 and C23; the 2-subset possesses a hydroxyl group at position 23 due to the hydration of the double bonds. They are considered to have very similar biological activities and toxicological properties. It is the mixture of 22,23-dihydro-avermectin B1a (at least 90%) and 22,23-dihydro-avermectin B1b (less than 10 %), differing by a single methylene group at 26 position. These are also known as 5-O-demethyl-22,23-dihydro-avermectin A1a and 5-O-demethyl-22,23-dihydro- avermectin A1b respectively. Ivermectin is a white to yellowish crystalline powder; nonhygroscopic; melting point 155 C; insoluble in water; soluble in methanol and ethanol. Doramectin has the closer structural similarity with abamectin than ivermectin. There is a different substituent at the 25 position without the dihydro modification at the 22,23 position. Doramectin is used as an endoparasitic agent in non-lactating cattle. Eprinomectin is the amino-avermectin derived from avermectin B1 with modified terminal oleandrose moiety. It is the mixture of 4"-epiacetylamino-4"-deoxy-avermectin B1a (> 90%) and B1b (< 10%).

 

APPLICATION

Ivermectin is the most common avermectin. It is a broad spectrum antiparasitic drug for oral administration. It is sometimes used to treat human onchocerciasis.
Avermectins are insecticidal or anthelmintic compounds for domestic animals and sometimes humans.

It is a new style antihelmintic parasiticide and miticide. Ivermectin paralyzes and ultimately kills parasitic nematodes, arachnoids and insects by a unique effect on the nervous systems of these parasites. Only one time use can treatment and control internal and eternal parasite. Not only it can promote growth and gain body weight of livestock, but also their fur become soft and bright after using Ivermectin.

 

SPECIFICATION & PACKING

APPEARANCE: white to off-white crystalline powder

IDENTIFICATION: Complies

ASSAY: B1a + B1b : 95.0% min (B1a : 90.0% min)

OPTICAL ROTATION: -17° ~ -20°

RELATED SUBSTANCE: 5.0% max

ETHANOL: 5.0% max

FORMAMIDE: 3.0% max

RESIDUE ON IGNITION: 0.1% max

HEAVY METALS: 20ppm max

LOSS ON DRYING: 1.0% max
Packing: 1kg or 5kg in one Al-sealed tin, 10kg per carton.

Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate locked safety storage cabinet or room.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

Section 1: Chemical Product and Company Identification

Product Name: Ivermectin

CAS#: 70288-86-7

Synonym: 22,23-Dihyroavermectin B1

Chemical Name: Ivermectin

Chemical Formula: Not available.

 

Section 2: Composition and Information on Ingredients

Composition:

Name          CAS #           % by Weight

Ivermectin      70288-86-7            100

Toxicological Data on Ingredients: Ivermectin: ORAL (LD50): Acute: 29.5 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:

Slightly hazardous in case of skin contact (irritant), of eye contact (irritant). Severe over-exposure can result in

death.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available.

MUTAGENIC EFFECTS: Classified None. for human. Non-mutagenic for mammalians.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/male [POSSIBLE]. Classified

Reproductive system/toxin/female [None.].

Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.

Section 4: First Aid Measures

Eye Contact: No known effect on eye contact, rinse with water for a few minutes.

Skin Contact:

After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin

with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.

Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated

clothing before reusing.

Serious Skin Contact: Not available.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. Seek medical attention.

Ingestion:

Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible

indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen

tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth

resuscitation. Seek immediate medical attention.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: Not available.

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill: Use a shovel to put the material into a convenient waste disposal container.

Section 7: Handling and Storage

Precautions:

Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,

evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not

breathe dust. Wear suitable protective clothing If ingested, seek medical advice immediately and show the

container or the label.

Storage:

Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly

closed. Keep in a cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate locked safety storage cabinet or room.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid.

Odor: Not available.

Taste: Not available.

Molecular Weight: Not available.

Color: Off-white.

pH (1% soln/water): Not applicable.

Boiling Point: Not available.

Melting Point: Not available.

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, acetone.

Solubility:

Soluble in acetone.

Very slightly soluble in hot water, n-octanol.

Insoluble in cold water, methanol.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Not available.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 29.5 mg/kg [Mouse].

Chronic Effects on Humans:

MUTAGENIC EFFECTS: Classified None. for human. Non-mutagenic for mammalians.

DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/male [POSSIBLE]. Classified

Reproductive system/toxin/female [None.].

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: Not available.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: CLASS 6.1: Poisonous material.

Identification: : Toxic solids n.o.s. (Ivermectin) : UN2811 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: No products were found.

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).

DSCL (EEC):

R40- Possible risks of irreversible

effects.

R62- Possible risk of impaired fertility.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 3

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an

approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Safety glasses.


Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

SPECIAL DESCRIPTION

Avermectin class acaricides or insecticides include:

AVERMECTIN PRODUCTS

Product

CAS RN

(23S)-25-De(1-methylpropyl)-22,23-dihydro-23-hydroxy-25- (1-methylethyl) avermectin A1a

65195-54-2

(23S)-22,23-Dihydro-23-hydroxyavermectin A1a

65195-53-1

22,23-Dihydroavermectin B1a

71827-03-7

25-De(1-methylpropyl)-25-(1-methylethyl)avermectin A1a

65195-52-0

27-Hydroxyavermectin

109084-58-4

4''-Epiacetylamino-4''-deoxyavermectin B1

160902-72-7

5-O-Demethylavermectin A1a

65195-55-3

Abamectin

71751-41-2

Avermectin

73989-17-0

Avermectin A1

71751-39-8

Avermectin A1a

65195-51-9

(4''R)- 22,23-Dihydro-4''-(acetylamino)-5-O-demethyl-4''-deoxy-26- ((2-methoxyethoxy) methoxy)avermectin A1a

148865-44-5

(13R,23S)- 22,23-dihydro-5-O-demethyl-23-hydroxyavermectin A1a

135680-93-2

22,23-Dihydro-5-O-demethyl-26-((2-methoxyethoxy)methoxy) avermectin A1a

156153-56-9

(8Z)-3'',5-di-O-demethylavermectin A1a

123237-30-9

(4''R)-4''-(Acetylamino)-26-(benzoyloxy)-5-O-demethyl-4''-deoxyavermectin A1a

148864-94-2

(4''R)-4''-(Acetylamino)-5-O-demethyl-4''-deoxy-26-((2-methoxyethoxy) methoxy) avermectin A1a

148865-00-3

(4''R)-4''-(Acetylamino)-5-O-demethyl-4''-deoxy-26-methoxyavermectin A1a

156153-52-5

(13R)-5-O-Demethylavermectin A1a hydrate

135681-09-3

5-O-Demethyl-26-hydroxyavermectin A1a

86629-72-3

5-O-Demethyl-26-hydroxy-4''-O-((2-methoxyethoxy)methyl)avermectin A1a

148865-08-1

5-O-Demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)avermectin A1a

65195-56-4

(23S)-5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-23-hydroxy- 25-(1-methylethyl) avermectin A1a

65195-58-6

(4''R)-4''-Deoxy-4''-(methylamino)avermectin B1

119791-41-2; 137335-79-6

Avermectin B2

71751-42-3

Avermectin B2a

65195-57-5

Doramectin

117704-25-3

Emamectin benzoate

137512-74-4; 155569-91-8

Eprinomectin B1a

133305-88-1

Eprinomectin B1b

133305-89-2

Eprinomectin

123997-26-2

Ivermectin B1a

70161-11-4

Ivermectin B1b

70209-81-3

Ivermectin luminol

122047-12-5

Ivermectin

70288-86-7

Selamectin

220119-17-5; 165108-07-6