|
|
||||
|
SYNONYMS: |
DES; 4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol |
|
|
|
|
CAS NO.: |
56-53-1 |
|
||
|
EINECS NO.: |
200-278-5 |
|
||
|
FORMULA: |
C18H20O2 |
|
||
|
H.S. CODE: |
N/A |
|
||
|
CLASS NO.: |
N/A |
|
||
|
UN NO.: |
N/A |
|
||
|
NFPA: |
1-1-0-E |
|
||
|
DESCRIPTION: |
Clear to slightly hazy colorless to faint yellow solution at 100mg/ml in methanol. |
|||
|
|
||||
|
APPLICATION |
||||
|
Synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone |
||||
|
SPECIFICATION & PACKING |
||||
|
CHARACTERISTICS:THE COLOURLESS CRYSTAL,EITHER THE WHITE CRYSTAL POWDERS IDENTIFICATION: POSITIVE ACID BASICITY: NEUTRALITY IS REACTED MONO-AND DIMETHYL ETHERS: COMPLIES 4,4-DIHYDROXYSTIBENE AND RELATED ETHERS: 325nm A≤0.50 ORGANIC VOLATILE IMPURITIES: COMPLIES MELTING POINT: 169~175? LOSS ON DRYING: 0.5%MAX. SULPHATED ASH: 0.1%MAX. ASSAY:
97.0~100.5% (C18H20O2) Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Carcinogenic, eratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room. |
||||
|
RAW MATERIAL: |
N/A |
|||
|
END GOODS: |
N/A |
|||
|
REMARKS: |
N/A |
|||
|
MATERIAL SAFE DATA SHEETS |
||||
Section 1: Chemical Product and Company Identification
Product Name: Diethylstilbestrol
CAS#: 56-53-1
Synonym: DES; 4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol
Chemical Name: Not available.
Chemical Formula: C18H20O2
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Diethylstilbestrol 56-53-1 100
Toxicological
Data on Ingredients: Diethylstilbestrol LD50: Not available. LC50:
Not available.
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of ingestion. Hazardous in case of skin contact (permeator). Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
Potential Chronic Health Effects:
Very hazardous in case of ingestion.
Hazardous in case of skin contact (permeator).
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
CARCINOGENIC EFFECTS: Classified 1 (Known.) by NTP.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: PROVEN
The substance is toxic to the reproductive system.
Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used.
Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated
clothing before reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation: Not available.
Ingestion:
Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Material in powder form, capable of creating a dust explosion.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with skin Wear suitable protective clothing If you feel unwell, seek medical attention and show the label when possible.
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Carcinogenic, eratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Solid powder.)
Odor: Not available.
Taste: Not available.
Molecular Weight: 268.34 g/mole
Color: White.
pH (1% soln/water): Not available.
Boiling Point: Decomposes.
Melting Point: 171°C (339.8°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol, diethyl ether.
Solubility:
Soluble in methanol, diethyl ether.
Very slightly soluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.
Section 11: Toxicological Information
Routes of Entry: Dermal contact. Ingestion.
Toxicity to Animals:
LD50: Not available.
LC50: Not available.
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: Classified 1 (Known.) by NTP.
DEVELOPMENTAL TOXICITY: PROVEN
The substance is toxic to the reproductive system.
Other Toxic Effects on Humans:
Very hazardous in case of ingestion.
Hazardous in case of skin contact (permeator).
Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Diethylstilbestrol
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer which would require a warning under the statute: Diethylstilbestrol
TSCA 8(b) inventory: Diethylstilbestrol
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
DSCL (EEC): R45- May cause cancer.
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate.
Safety glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
|
CERTIFICATE OF ANALYSIS |
||||
|
PRODUCT |
DIETHYLSTILBESTROL |
STANDARD |
BP/USP |
|
|
BATCH NO. |
20080901 |
MANUFACTURE DATE |
SEPT.15,2008 |
|
|
QUANTITY |
2KGS |
EXPIRY DATE |
SEPT.14,2011 |
|
|
PACKING |
2KGS/BAG |
REPORT DATE |
SEPT.16,2008 |
|
|
ITEMS |
SPECIFICATION |
RESULTS |
|
CHARACTERISTICS |
THE COLOURLESS CRYSTAL,EITHER THE WHITE CRYSTAL POWDERS |
COMPLIES |
|
IDENTIFICATION |
POSITIVE |
COMPLIES |
|
ACID BASICITY |
NEUTRALITY IS REACTED |
COMPLIES |
|
4,4-DIHYDROXYATIBENE AND RELATED ETHERS |
A≤0.5% |
COMPLIES |
|
MELTING POINT |
169-172? |
169-172? |
|
LOSS ON DRYING |
=0.5% |
0.4% |
|
SULPHATED ASH |
=0.1% |
0.05% |
|
ASSAY |
98% MIN |
99.5% |
|
ORGANIC VOLATILE IMPURITIES |
COMPLIES |
COMPLIES |
|
CONCLUSION:CONFORM WITH THE BP1998/USP26 STANDARD |