Aspartame|Ronas Chemicals Ind.Co.,Ltd.

MSDS of Aspartame

Material Safety Data Sheets of Aspartame

MSDS Name: L-Aspartyl-l-phenylalanine methyl ester, 98%

**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

The molecular formula of aspartame is C14H18N2O5

Company Identification: Acros Organics N.V.
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
For information in North America, call: 800-ACROS-01
For information in Europe, call: 0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies outside the US, call: 0032(0) 14575299

**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

CAS#	Chemical Name	%	EINECS#
22839-47-0	L-ASPARTYL-L-PHENYLALANINE METHYL ESTE R 98%	98	245-261-3

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Not available.
Appearance: Sweet white powder.
Not available.
Target Organs: Skin.

Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully
investigated.
Inhalation:
May cause respiratory tract irritation.
Chronic:
Repeated exposure may cause sensitization dermatitis.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically.
None reported.

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
In case of fire use water spray, dry chemical, carbon dioxide, or
chemical foam.
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

**** SECTION 7 - HANDLING and STORAGE ****

Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a tightly closed container. Store in a dry area.
Refrigerator (approx 4_C).

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.

Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
L-ASPARTYL-L-PHENYL ALANINE METHYL ESTE R,98%	none listed	none listed	none listed

OSHA Vacated PELs:
L-ASPARTYL-L-PHENYLALANINE METHYL ESTER,98%:
No OSHA Vacated PELs are listed for this chemical.

Personal Protective Equipment

Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear a chemical apron.
Respirators: A NIOSH/MSHA approved air purifying dust or mist respirator.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Not available.
Appearance: Sweet white powder
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 248.00 - 250
Decomposition Temperature: Not available. Anything above freezing?
Solubility: sparingly soluble
Specific Gravity/Density: Not available.
Molecular Formula: MISDO
Molecular Weight: 294.30

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Not available.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Methanol, Formaldehyde and DKP (tumor agent)
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Not available.

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#: CAS# 22839-47-0: WM3407000
LD50/LC50: Not available.
Carcinogenicity: L-ASPARTYL-L-PHENYLALANINE METHYL ESTER,98% -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Reproductive Effects: orl-mus TDLo:4 g/kg (15-18 D preg) orl-gpg TDLo:32500 mg/kg (1-65 D preg) orl-wmn TDLo:3710mg/kg

**** SECTION 12 - ECOLOGICAL INFORMATION ****

**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration of Contaminants: Not listed.
RCRA D-Series Chronic Toxicity Reference Levels: Not listed.
RCRA F-Series: Not listed.
RCRA P-Series: Not listed.
RCRA U-Series: Not listed.
Not listed as a material banned from land disposal according to RCRA.

**** SECTION 14 - TRANSPORT INFORMATION ****

US DOT : No information available
IMO: No information available.
IATA: No information available.
RID/ADR: No information available.
Canadian TDG: No information available.

**** SECTION 15 - REGULATORY INFORMATION ****

A. Federal
TSCA
CAS# 22839-47-0 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
B. State

Not present on state lists from CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level:
None of the chemicals in this product are listed.
C. International
Canada
CAS# 22839-47-0 is listed on Canada's DSL/NDSL List.
CAS# 22839-47-0 is not listed on Canada's Ingredient Disclosure List.
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
Exposure Limits:
OEL-AUSTRALIA:TWA 500 ppm (1185 mg/m3);STEL 1000 ppm. OEL-AUSTRIA:TWA
750 ppm (1780 mg/m3). OEL-BELGIUM:TWA 750 ppm (1780 mg/m3);STEL 1000 p
p. OEL-CZECHOSLOVAKIA:TWA 800 mg/m3;STEL 4000 mg/m3. OEL-DENMARK:TWA 2
50 ppm (600 mg/m3). OEL-FINLAND:TWA 500 ppm (1200 mg/m3);STEL 625 ppm
(1500 mg/m3). OEL-FRANCE:TWA 750 ppm (1800 mg/m3). OEL-GERMANY:TWA 100
0 ppm (2400 mg/m3). OEL-HUNGARY:TWA 600 mg/m3;STEL 1200 mg/m3. OEL-IND
IA:TWA 750 ppm (1780 mg/m3);STEL 1000 ppm (2375 mg/m3). OEL-JAPAN:TWA
200 ppm (470 mg/m3). OEL-THE NETHERLANDS:TWA 750 ppm (1780 mg/m3) JAN9
. OEL-THE PHILIPPINES:TWA 1000 ppm (2400 mg/m3). OEL-POLAND:TWA 200 mg
/m3. OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3. OEL-SWEDEN:TWA 250 ppm (60
0 mg/m3);STEL 500 ppm (1200 mg/m3). OEL-SWITZERLAND:TWA 750 ppm (1780
mg/m3). OEL-TURKEY:TWA 1000 ppm (2400 mg/m3). OEL-UNITED KINGDOM:TWA 1
000 ppm (2400 mg/m3);STEL 1250 ppm. OEL IN BULGARIA, COLOMBIA, JORDAN,
KOREA check ACGIH TLV. OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check A
CGI TLV

**** SECTION 16 - ADDITIONAL INFORMATION ****

Additional Information:
No additional information available.