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 ALBENDAZOLE

SYNONYMS:

Methyl 5-propylthio-2-benzimidazolecarbamate;

 

 

CAS NO.:

54965-21-8    (Base)

 

EINECS NO.:

259-414-7

 

FORMULA:

C12H15N3O2S  

 

H.S. CODE:

29332950

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

1-1-0

 

DESCRIPTION:

It is a white to off-white powder;  insoluble in water;  soluble in dimethylsulfoxide,  strong acids and strong bases;  slightly soluble in methanol, chloroform,  ethyl acetate and acetonitrile.  Chemical designation is Methyl 5-(propylthio)-2-benzimidazolecarbamate.

 

APPLICATION

Albendazole is an orally administered broad-spectrum benzimidazole anthelmintic used against helminths and in the treatment of hydatid cyst disease and neurocysticercosis. It is used to treat ruminant infestations by either roundworms or flatworms.

SPECIFICATION & PACKING

APPEARANCE: white to off-white powder 

IDENTIFICATION: Complies Test A, B

ASSAY: 98.0 - 101.0%

MELTING POINT: 208 - 210 C

RESIDUE ON IGNITION: 0.2% max

ASH: 0.2% max
Packing:
Storage: Keep tightly closed.Store in a cool dry place

RAW MATERIAL:

1) Cyanamide and hydrogen and methyl chloroformate and 1-propanethiol

2) 1-bromopropane and cyanamide and dimethylsulfoxide,stable isotopes and isopropyl alcohol and methyl chloroformate and 1-propanol

3) Hydrazine hydrate and methyl chloroformate and 1-propanethiol and thiourea

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

MATERIAL SAFETY DATA SHEET
Section 1 Identification

Product name:albendazole

 

Section 2 Hazard Identification

May cause harm to the unborn child.

Irritating to eyes, respiratory system and skin.

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Wear suitable protective clothing, gloves and eye/face protection.

Do not breathe dust.

 

Section 3 First Aid Measures

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

 

Section 4 Fire Fighting Measures

Extinguishing media

Water spray.

Carbon dioxide, dry chemical powder or appropriate foam.

Special firefighting procedures

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Unusual fire and explosions hazards

Emits toxic fumes under fire conditions.

 

Section 5 Accidental Release Measures

Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves.

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust.

Ventilate area and wash spill site after material pickup is complete.

 

Section 6 Handling and Storage

Handling see section 7.

Storage :Keep tightly closed.Store in a cool dry place

 

Section 7 Exposure Controls & Personal

Wear appropriate respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Use only in a chemical fume hood.

Safety shower and eye bath.

Do not breathe dust.

Do not get in eyes, on skin, on clothing.

Wash thoroughly after handling.

 

Section 8 physicual and chemical properties

Appearance: White or almost white solid, odor.

Melting point: 208 to 210'c

 

Section 9 toxicological information

Acute effects

May be harmful by inhalation, ingestion, or skin absorption.

Causes eye and skin irritation.

Material is irritating to mucous membranes and upper respiratory tract.

Chronic effects

May cause congenital malformation in the fetus.

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Toxicity data

Orl-rat LD50:2400 mg/kg

Ivn-rat LD50:265 mg/kg

Orl-mus ld50:1500 mg/kg

Orl-ham ld50:>10 gm/kg

 

Section 10 stability and reactivity

Stability

Stable.

Hazardous combustion or decomposition products toxic fumes of:

Carbon monoxide, carbon dioxide

Nitrogen oxides

Sulfur oxides

Hazardous polymerization will not occur.

 

Section 11 other information

This MSDS summary is best knowledge of the health and safety hazard information of the product, and in particular how to safely handle and use the product in the workplace. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide.

SPECIAL DESCRIPTION

Anthelmintic (also spelled  anthelminthic) is a chemical substance used to expel or destroy tapeworms in domestic animals. Some common anthelmintic active ingredients classified by chemical structure include;